Substituted 2-phenylamino-2-imidazolines and salts thereof

US4361575A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Helmut Stahle
• Herbert Koppe · Ingelheim am Rhein, DE
• Werner Kummer · Ingelheim am Rhein, DE
• Walter Kobinger · Wien, AT
• Christian Lillie · Wien, AT
• Ludwig Pichler · Wien, AT
• Wolfgang Hoefke · Wiesbaden, DE
• Wolfram Gaida · Ingelheim am Rhein, DE

Key dates

• Filing date: Jun 23, 1981
• Grant date: Nov 30, 1982
• Expiry date: Jun 23, 2001

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, hydroxyl or amino; PA1 R.sub.4 is straight or branched alkyl of 1 to 5 carbon atoms, allyl or benzyl; PA1 R.sub.5 is methyl, ethyl or 2-dimethylamino-ethyl; and PA1 n is 0 or 1; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.