Agglutination immunoassays carried out with agent to reduce non-specific interferences
US4362531A · kind A · utility
42Cited by
6References
19Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 14, 1981 |
| Grant date | Dec 7, 1982 |
| Priority date | — |
| Expiry date | Apr 14, 2001 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/825
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
In particle agglutination immunoassays for an analyte (e.g. an antigen or antibody) in a liquid sample (e.g. human serum), interferences arise due to non-specific protein-protein interactions and the like. These interferences are reduced or overcome by including in the assay mixture a chaotropic or chaotropic-like agent, in a carefully controlled amount. Such agents include guanidine, guanidinium hydrochloride or thiocyanate, sodium or ammonium thiocyanate, and urea, sodium chloride and ethylenediamine tetraacetic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.