Cephalosporins

US4362725A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Bernd Wetzel · Biberach an der Riß, DE
• Eberhard Woitun · Biberach an der Riß, DE
• Wolfgang Reuter
• Roland Maier · Biberach an der Riß, DE
• Uwe Lechner · Biberach an der Riß, DE
• Hanns Goeth · Biberach an der Riß, DE

Key dates

• Filing date: Sep 28, 1981
• Grant date: Dec 7, 1982
• Expiry date: Sep 28, 2001

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein A is phenyl, 4-hydroxy-phenyl, 2-thienyl, 2-furyl or 3,4-dihydroxy-phenyl; PA0 Y is hydrogen or methoxy; PA0 Het is 4H-5,6-dioxo-1,2,4-triazin-3-yl, PA0 4-methyl-5,6-dioxo-1,2,4-triazin-3-yl, PA0 2-methyl-5,6-dioxo-1,2,4-triazin-3-yl, PA0 1-vinyl-tetrazol-5-yl, 1-allyl-tetrazol-5-yl or ##STR2## where n is an integer from 1 to 3, inclusive PA0 R.sub.1 is hydroxyl, amino, dimethylamino, acetylamino, aminocarbonyl, aminocarbonylamino, aminosulfonyl, aminosulfonylamino, methylcarbonyl, methylsulfonylamino, cyano, hydroxysulfonylamino, methylsulfonyl, methylsulfinyl, a carboxylic acid group or a sulfonic acid group, and PA0 --(CH.sub.2).sub.n --R.sub.1 may also be alkyl of 2 to 4 carbon atoms or 2,3-dihydroxy-propyl; PA0 R is cyclopropyl, 4'-hydroxycyclohexyl-amino ##STR3## where R.sub.2 is straight or branched, saturated or unsaturated hydrocarbyl of 1 to 4 carbon atoms or cycloalkyl of 3 to 6 carbon atoms; PA0 G is hydroxyl, aminocarbonyl, aminosulfonyl, aminocarbonylamino, acetylamino, methylsulfonylamino, methylsulfinyl or methylsulfonyl; PA0 m is 0 or 1; and PA0 R.sub.3 and R.sub.4, which may be identical to or different from each other, ar…