Transdermal carrier materials

US4362737A · kind A · utility

Inventors

• Rolf Schafer
• Werner Schafer · Essen, DE
• Doris Schafer · Arisdorf, CH

Key dates

• Filing date: Apr 13, 1981
• Grant date: Dec 7, 1982
• Expiry date: Apr 13, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6506
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Amphoteric dissociating complexes which have a cationic group having the structure ##STR1## wherein: R.sub.1 is an aliphatic alkyl group having 6 to 22 carbons, PA1 R.sub.2 is a member of the group consisting of --R.sub.4 --(CH.sub.2 CH.sub.2)--COOH, --R.sub.4 --(CH.dbd.CH)COOH and --OPO.sub.3 H.sub.2, wherein R.sub.4 is --NH--, --NH--CO--, or --O--CO--, and PA1 R.sub.3 is hydrogen, --CH.sub.2 --COOH or --CH.sub.2 --CH.sub.2 --COOH; and an anionic group which is either a carboxylate having the formula EQU .sup.- OOC--CH.sub.2 --(O--CH.sub.2 --CH.sub.2).sub.x --OC.sub.n H.sub.2n+1 PA1 or a phosphate having the formula EQU .sup.= O.sub.3 PO--CH.sub.2 --CH.sub.2 --(OCH.sub.2 --CH.sub.2).sub.x --OC.sub.n H.sub.2n+1 PA1 wherein: PA1 n is 8 to 22 and x is 1 to 10; and z is 1 when the anionic radical is a carboxylate and z is 2 when the anionic radical is a phosphate are disclosed. The compositions are effective carriers for active pharmaceutical or cosmetic ingredients. The active ingredients may be ionically complexed with the cationic or anionic group of the amphoteric complex or may be covalently bonded to one of the groups of the complex. Alternatively, the active substances may be t…