Chemical process
US4362880A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 30, 1981 |
| Grant date | Dec 7, 1982 |
| Priority date | — |
| Expiry date | Mar 30, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C45/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved process for the preparation of 3-substituted thiophenes. The thiophenes are useful for the preparation of penicillins and cephalosporins. The process is for the preparation of a thiophene of formula (I): ##STR1## where R.sup.1 represents a carboxylic acid group, or an ester or amide thereof or a nitrile group; R.sup.2 represents a group suitable for use as an .alpha.-substituent in the side-chain of a penicillin or cephalosporin; which comprises treating under basic conditions a compound of formula (II): ##STR2## wherein X represents halogen or optionally functionalized hydroxyl, Y represents halogen, hydroxyl, or alkoxy; with a source of nucleophilic sulphur ionically bound to a polymeric support.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.