Triiodinated 5-aminoisophthalic acid derivatives

US4367216A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Wolfgang Mutzel · Berlin, DE
• Hans-Martin Siefert · Berlin, DE
• Ulrich Speck · Berlin, DE
• Heinrich Pfeiffer · Eppingen, DE
• Paul-Eberhard Schulze
• Bernhard Acksteiner · Berlin, DE

Key dates

• Filing date: Jun 27, 1980
• Grant date: Jan 4, 1983
• Expiry date: Jun 27, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/0838
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sup.1 is hydroxy-C.sub.2-8 -alkyl containing 1-5 OH-groups; PA1 R.sup.2 is hydrogen, C.sub.1-4 -alkyl or R.sup.1 ; PA1 R.sup.3 and R.sup.4 can be identical or different, and each independently is hydrogen or C.sub.1-4 -alkyl; and PA1 X is straight chain or branched C.sub.2-12 alkylene interrupted by sulfur or selenium atoms, and, optionally, additionally interrupted by oxygen atoms, by a di(C.sub.1-4 -alkyl)silyl group or a tetra(C.sub.1-4 -alkyl)disiloxane group; PA1 are very useful as X-ray contrast media opaque agents, which can be employed even in lymphography.