Novel antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin
US4367225A · kind A · utility
20Cited by
9References
17Claims
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Key dates
| Filing date | Mar 24, 1981 |
| Grant date | Jan 4, 1983 |
| Priority date | — |
| Expiry date | Mar 24, 2001 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds acting as antagonists of the antidiuretic activity of arginine vasopressin are those of the formula ##STR1## wherein X is methyl, ethyl, n-propyl, isopropyl or butyl; Tyr is D- or L-; W is Pro or .DELTA..sup.3 -Pro; and Z is L- or D- Arg. Related compounds in which X is H, methyl or ethyl; W is Pro and Val at the 4-position is replaced by Gln- have antivasopressor activity against arginine vasopressin. Compounds wherein D-Tyr is unetherified (X is H), W- is Pro and Z- is D- or L-Arg also act as antagonists of the antidiuretic activity of arginine vasopressin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.