Preparation of 4-haloazetidin-2-ones from 4-sulfinoazetidin-2-ones
US4368156A · kind A · utility
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4References
21Claims
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Key dates
| Filing date | Mar 9, 1981 |
| Grant date | Jan 11, 1983 |
| Priority date | — |
| Expiry date | Mar 9, 2001 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for 4-halo azetidinones of the formula ##STR1## wherein R.sub.1 is acylamino or diacylamino, X is chloro, bromo or iodo, and R is a carboxy-protecting group which comprises treating a 4-sulfinoazetidinone of the formula ##STR2## with positive halogen reagent, eg. N-chlorosuccinimide, N-bromosuccinimide, N-iodosuccinimide, hypohalite. The 4-haloazetidinones are useful intermediate for .beta.-lactam antibiotics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.