Zinc aminophylline and its use in the treatment of bronchospasms
US4368197A · kind A · utility
14Cited by
9References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 7, 1980 |
| Grant date | Jan 11, 1983 |
| Priority date | — |
| Expiry date | Nov 7, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is disclosed zinc complexes of amine salts of theophylline. The preferred compound disclosed is the zinc complex of aminophylline. These compounds are useful as bronchodilators and have antibronchospasmotic activity. They are substantially insoluble and do not impart an unpleasant taste to oral formulations. In addition, they are storage stable. The compounds are prepared by reacting a water soluble simple zinc salt with the amine salt of theophylline at temperatures of from 60.degree.-90.degree. C. for about 8 to 16 hours.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.