Glucosamine peptide derivatives, their production and use
US4369178A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 21, 1980 |
| Grant date | Jan 18, 1983 |
| Priority date | — |
| Expiry date | Feb 21, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel glucosamine-peptide derivatives of the formula: ##STR1## wherein m is 0 or 1; PA1 n is 0 or an integer of 1 to 9; PA1 R is lower alkyl which may be substituted with hydroxyl, or aryl; PA1 R.sup.1 is hydrogen or acyl having an acyclic hydrocarbon group, the terminal of which may be substituted with a cyclic hydrocarbon group directly, via a carbonyl group or via an oxygen atom; PA1 provided that when R.sup.1 is hydrogen m is 1; PA1 R.sup.2 is hydrogen or lower alkyl which may form a ring by connecting its terminal with the .alpha.-nitrogen atom when PA1 n is 0, or hydrogen when n is an integer of 1 to 9; PA1 R.sup.3 is hydrogen or lower alkyl; PA1 R.sup.4 and R.sup.5 are each hydrogen or lower alkyl which may be substituted with hydroxyl or benzyloxyl; PA1 R.sup.6 is hydrogen or lower alkyl; PA1 R.sup.7 is alkyl which may be substituted with lower alkoxyl or aralkyl; PA1 R.sup.8 and R.sup.9 are each hydrogen, lower alkyl or aralkyl; and PA1 (D) and (L) each indicate configurations if their respective carbon atoms are asymmetric; or an acid addition salt thereof, have immunostimulatory activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.