Method for the cold sterilization of preparations containing blood coagulation factor VIII

US4370264A · kind A · utility

Assignee

• Biotest-Serum-Institut GmbH

Inventors

• Ronald Kotitschke · Dreieich, DE
• Wolfgang Stephan · Heidelberg, DE

Key dates

• Filing date: Sep 8, 1981
• Grant date: Jan 25, 1983
• Expiry date: Sep 8, 2001

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/831
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A process for the cold sterilization of a preparation containing blood coagulation factor VIII, comprising PA1 (A) contacting a protein solution containing factor VIII with a physiologically compatible, non-ionogenic tenside, and then subjecting the solution to PA1 (B) irradiation with ultraviolet light, PA1 (C) treatment with beta-propiolactione, and PA1 (D) to an adsorption treatment with colloidal silica, steps B-C-D being performed in the sequence B-C-D, B-D-C, D-C-B or D-B-C.