Pancreatic spasmolytic polypeptide
US4370317A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 9, 1981 |
| Grant date | Jan 25, 1983 |
| Priority date | — |
| Expiry date | Mar 9, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a novel purified polypeptide which is recoverable from porcine pancreas glands. The amino acid composition of the said polypeptide has been determined to be as follows: Trp (2), Lys (4), His (1), Arg (5), Asx (10), Thr (3), Ser (9), Glx (12), Pro (12), Gly (6), Ala (6), Cys 1/2 (14), Val (7), Met (2), Ile (3), Leu (1), Try (2), Phe (7), wherein the determinations are subjected to the usual error of .+-.10 percent of the indicated figures. The partial amino acid sequence comprising a total of 45 amino acids from the N-terminal, is believed to be: ##STR1## wherein pyrGlu (residue 1) stands for pyroglutamic acid. The purified polypeptide is of utility as a medicament, for example as a spasmolytic agent, as an agent for treatment of gastroduodenal ulcers and as a diagnostic aid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.