Preparation of .alpha.-ketocarboxylic acid N-acylamides

US4370498A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Gerhard Bonse · Neunburg vorm Wald, DE
• Heinz U. Blank · Odenthal, DE

Key dates

• Filing date: Feb 19, 1981
• Grant date: Jan 25, 1983
• Expiry date: Feb 19, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C51/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

.alpha.-Ketocarboxylic acid N-acylamides of the formula EQU R.sup.1 --CO--CO--NH--CO--R.sup.2 in which PA1 R.sup.1 is an optionally substituted aliphatic radical with up to 12 carbon atoms, an optionally substituted cycloalkyl radical with 3 to 10 carbon atoms, an optionally substituted heterocyclic radical, and PA1 R.sup.2 is an optionally substituted aliphatic radical with up to 8 carbon atoms or an optionally substituted phenyl radical, are prepared by reacting an acyl cyanide of the formula EQU R.sup.1 --CO--CN with a carboxylic acid anhydride of the formula EQU R.sup.2 --CO--O--CO--R.sup.2 in the presence of a strong acid, and then adding water to the reaction mixture. The products can be used directly in the synthesis of known herbicides.