N4-Substituted tetrahydro-1,2,4-oxadiazin-5-one derivatives having anticonvulsive activity and pharmaceutical compositions containing them
US4371534A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 29, 1981 |
| Grant date | Feb 1, 1983 |
| Priority date | — |
| Expiry date | Dec 29, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to new tetrahydro-1,2,4-oxadiazin-5-one derivatives having a CNS activity. More particularly, the invention concerns new N.sup.4 -substituted tetrahydro-1,2,4-oxadiazin-5-ones of the formula (1) ##STR1## wherein R.sup.2 is benzyloxycarbonyl or alkylcarbonyl containing 1 to 4 carbon atoms in the alkyl moiety, preferably acetyl; PA1 R.sup.3 is phenyl optionally substituted with 1 to 3 lower alkoxy groups; and PA1 R.sup.4 is an aliphatic or cyclic alkyl group having 1 to 11 carbon atoms, hydroxymethyl, halomethyl or acyloxymethyl. According to another aspect of the invention there are provided processes for the preparation of compounds of formula (1). Still another aspect of the invention is a pharmaceutical composition which comprises as active ingredient a compound of formula (1).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.