Process for the production of isosorbide-5-nitrate
US4371703A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 7, 1982 |
| Grant date | Feb 1, 1983 |
| Priority date | — |
| Expiry date | Jan 7, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a process for the production of isosorbide-5-nitrate comprising PA0 (a) subjecting an acylation mixture of isosorbide containing varying proportions of isosorbide, isosorbide-2-acylate, isosorbide-5-acylate and/or isosorbide-2,5-diacylate, or pure isosorbide-5-acylate or an equimolar mixture of isosorbide-2,5-diacylate and isosorbide to a transacylation reaction in the presence of a catalyst and removing the isosorbide-2-acylate present from the reaction mixture by fractional distillation; PA0 (b) optionally subjecting the separated isosorbide-2-acylate to a further purification step; PA0 (c) esterifying the obtained isosorbide-2-acylate with nitric acid; and PA0 (d) partially hydrolyzing the obtained isosorbide-2-acylate-5-nitrate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.