Process for the production of peptides

US4374062A · kind A · utility

Assignee

• Degussa AG · DE

Inventors

• Axel Kleemann · Hanau, DE
• Jurgen Martens · Alzenau, DE
• Marc Samson · Lokeren, BE

Key dates

• Filing date: Oct 14, 1981
• Grant date: Feb 15, 1983
• Expiry date: Oct 14, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K1/023
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

There are produced peptides by asymmetrical hydrogenation of dehydropeptides of the general formula ##STR1## in which n is a whole number from 1 to 4, R.sub.1 and R.sub.2 are the same or different, and are hydrogen, a straight or branched chain alkyl group with 1 to 10 carbon atoms, or such a group substituted with a carboxyl group, a phenyl group which is unsubstituted or substituted in the 3 or 4 position or in both the 3 and 4 positions by a hydroxyl, alkoxy, or acyloxy group or an indolyl group which is unsubstituted or substituted in the 6 position by fluorine or chlorine or an indolyl group substituted by a methyl group. R.sub.3 is hydrogen, an alkali metal, or a lower alkyl group with 1 to 4 carbon atoms, R.sub.4 is hydrogen, an acetyl group or a chloroacetyl group and R.sub.5 is hydrogen or a straight or branched chain alkyl group having 1 to 4 carbon atoms with the proviso that when n is 2, 3, or 4, the individual groups R.sub.5 are the same or different, in the presence of chiral rhodium-complexes.