Process for preparing artificial red cells
US4376059A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 11, 1980 |
| Grant date | Mar 8, 1983 |
| Priority date | — |
| Expiry date | Apr 11, 2000 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/101666
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for preparing artificial red cells comprising microdroplets of aqueous, stroma-free hemoglobin solution encapsulated in membranes of polymerized hemoglobin, said process comprising forming microdroplets of hemoglobin solution in a continuous oil phase, cross-linking the hemoglobin at the surface of the microdroplets with a suitable cross-linking agent to form the artificial red cells and recovering the cells. In one embodiment, a liquid membrane encapsulation technique employing a water-soluble cross-linking agent is used to form the cells. In another embodiment an oil-soluble cross-linking agent is present in the oil phase containing the hemoglobin microdroplets.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.