Patent · US Expired

1-Aziridine carboxylic acid derivatives with immunostimulant activity

US4376731A · kind A · utility

1Cited by

0References

8Claims

0Family size

Assignee

Boehringer Mannheim GmbH · DE

Inventors

Elmar Bosies · Weinheim, DE
Ruth Heerdt · Mannheim, DE
Rudi Gall · Hirschberg, DE
Uwe Bicker · Mannheim, DE
Anna E. Ziegler · Viernheim, DE

Key dates

Filing date	Jan 31, 1978
Grant date	Mar 15, 1983
Priority date	—
Expiry date	Jan 31, 1998

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D409/12
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

2-Substituted-1-aziridine-carboxylic acid esters exhibiting immuno-stimulant activity and of the formula ##STR1## wherein X is a carbamoyl or alkoxycarbonyl radical, and PA1 R.sup.1 is an aliphatic hydrocarbon radical optionally substituted by halogen, alkoxy, amino, carbamoyloxy, cycloalkyl, hydroxyl, an imido or heterocyclic radical, cycloalkyl; or aryl, aralkyl, aryloxyalkyl or arylthioalkyl wherein the aryl moiety is optionally substituted by halogen, alkyl, alkoxy, hydroxyl, amino, nitro, cyano, acyl, carbalkoxy, thioalkyl, alkylsulphonyl, phenyl or trifluoromethyl. Counterparts where X is --CN and R.sup.1 is as above, except for ethyl, are also new.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.