4-Aza-17.beta.-substituted-5.alpha.-androstan-3-one-reductase inhibitors
US4377584A · kind A · utility
154Cited by
4References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 23, 1980 |
| Grant date | Mar 22, 1983 |
| Priority date | — |
| Expiry date | Sep 23, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
4-Aza-17.beta.-substituted-5.alpha.-androstan-3-ones and their A-homo analogs of the formula: ##STR1## where Formula (I) may also have the structure of partial Formulas (II) and/or (III); and pharmaceutically acceptable salts of the above compounds are active as testosterone 5.alpha.-reductase inhibitors, and thus useful topically for treatment of acne, seborrhea, female hirsutism, and systemically in treatment of benign prostatic hypertrophy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.