Antitumor protein hybrid and process for the preparation thereof
US4379145A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Dec 15, 1980 |
| Grant date | Apr 5, 1983 |
| Priority date | — |
| Expiry date | Dec 15, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Antitumor protein hybrid, having a moiety consisting of the antitumor immunoglobulin and a moiety substantially consisting of the fragment A of a diphtheria toxin, which is expressed by the following formula (I): EQU Ab(NHCO--X--S.sub.1 --S.sub.2 --FA).sub.n (I) (where Ab indicates a moiety consisting of the antitumor immunoglobulin and FA indicates a moiety substantially consisting of the fragment A of a diphtheria toxin; X is an alkylene group or phenylene group which either has or does not have a branching of 1 to 5 carbon atoms. N in the amido bond is a nitrogen atom arising from the amino group in the antitumor immunoglobulin; S.sub.1 and S.sub.2 are both sulfur atoms, S.sub.2 indicating a sulfur atom arising from the disulfide bond in a diphtheria toxin; n stands for an integer of 1 to 5). This antitumor protein hybrid has remarkable and specific citotoxicity against tumor cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.