Process for introducing an oxygen-containing functional group into ansamycins
US4379149A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Sep 22, 1981 |
| Grant date | Apr 5, 1983 |
| Priority date | — |
| Expiry date | Sep 22, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
3-Hydroxyrifamycin S and its new analogues with an etherified or esterified 3-hydroxyl group of the formula ##STR1## in which each of R and R' represents a hydrogen atom, or R' represents acetyl and R represents hydrogen, an optionally substituted hydrocarbyl or the acyl radical of a carboxylic acid, and also the corresponding compounds of the SV series, are obtained by a novel process in which 3-bromorifamycin S is treated with a reagent ROH, in which R has the meanings mentioned above, or with a salt thereof, in a neutral to weakly basic medium. The final products are primarily suitable as antibiotics for combating microbial infections and/or as intermediates for the manufacture of the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.