3,5-Disubstituted-1H-1,2,4-triazole derivatives
US4379155A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 17, 1981 |
| Grant date | Apr 5, 1983 |
| Priority date | — |
| Expiry date | Jul 17, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New 3,5-disubstituted 1H-1,2,4-triazoles of formula I ##STR1## wherein: R is selected from hydrogen, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, allyloxy, propargyloxy, trifluoromethyl, phenyl, fluoro, chloro and dimethylamino; PA1 R.sub.1 represents a (C.sub.1-4)alkyl group; PA1 R.sub.2 is selected from hydrogen, fluoro, chloro, (C.sub.1-4)alkyl, methoxy and ethoxy; PA1 R.sub.3 is selected from hydrogen, fluoro, chloro, (C.sub.1-4)alkyl and (C.sub.1-4)alkoxy; PA1 R and R.sub.3 taken together represent a methylenedioxy group; with the proviso that, when R, R.sub.2 and R.sub.3 simultaneously represent hydrogen, R.sub.1 cannot be methyl; with the further proviso that, when R.sub.2 and one of R and R.sub.3 simultaneously represent hydrogen, R.sub.1 and the other of R and R.sub.3 cannot simultaneously represent methyl; and with the still further proviso that compounds of formula I are excluded wherein R.sub.2 is hydrogen and one of R and R.sub.3 is simultaneously a 2-positioned alkyl group and the other of R and R.sub.3 is hydrogen; and salts thereof with pharmaceutically acceptable acids. The compounds possess anti-reproductive utility.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.