Vasodilative 4-thia-PGI.sub.1 and 4-sulfinyl-PGI.sub.1 and derivatives thereof
US4379164A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 23, 1981 |
| Grant date | Apr 5, 1983 |
| Priority date | — |
| Expiry date | Oct 23, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P11/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A compound having vasodilative, bronchodilative, stomach-mucosa-protective and platelet-aggregation-inhibiting activity has the formula A 4-thia- or 4-sulfinyl-PGI.sub.1 -compound of the formula I ##STR1## wherein Q stands for --S-- or --SO--, PA0 A stands for C.sub.1-6 straight or branched chain alkylene, PA0 B stands for ethylene, vinylene or ethinylene, PA0 R.sup.1 represents hydrogen or C.sub.1-4 alkyl, PA0 R.sup.2 represents C.sub.1-8 straight or branched chain alkyl or mono-substituted aryl-oxy-methyl, PA0 R.sup.3 stands for hydrogen or acetyl, and PA0 Z represents --COOH, --CN, --CH.sub.2 OH or --COOW, wherein W stands for an equivalent of a pharmacologically acceptable cation or C.sub.1-4 alkyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.