2-Phenyl-pyrimidones

US4379788A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Joachim Heider · Warthausen, DE
• Volkhard Austel · Biberach, DE
• Wolfgang Eberlein · Biberach, DE
• Rudolf Kadatz · Zell am Harmersbach, DE
• Christian Lillie · Wien, AT

Key dates

• Filing date: Dec 4, 1981
• Grant date: Apr 12, 1983
• Expiry date: Dec 4, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein A and B, together with each other and the respective carbon atoms to which they are attached, form a phenyl or pyridine ring; PA0 R.sub.1 is hydrogen, halogen, amino, nitro, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms; PA0 R.sub.2 is hydrogen or alkoxy of 1 to 3 carbon atoms; PA0 D is alkylene of 3 to 4 carbon atoms or hydroxy(alkylene of 3 to 4 carbon atoms); PA0 R.sub.3 and R.sub.5, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 3 carbon atoms; PA0 R.sub.4 is hydrogen or alkoxy of 1 to 3 carbon atoms; and PA0 R.sub.6 is straight or branched alkyl of 1 to 6 carbon atoms or --E--R.sub.7 ; PA0 where E is straight alkylene of 2 to 4 carbon atoms or hydroxy-substituted straight alkylene of 2 to 4 carbon atoms, and PA0 R.sub.7 is ##STR2## where R.sub.8 and R.sub.9 are each hydrogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms; and non-toxic, pharmacologically acceptable acid addition salts thereof formed with inorganic or organic acids; the compounds as well as their salts are useful as hypotensives, antiarrhythmics and .beta.-receptor-blockers.