Process for the preparation of purified aminoglycoside antibiotics

US4380625A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Peter Stadler · Haan, DE
• Wolfgang Koebernick · Wuppertal, DE
• Samir Samaan · Wuppertal, DE
• Wolfgang Gau · Wuppertal, DE

Key dates

• Filing date: Dec 29, 1980
• Grant date: Apr 19, 1983
• Expiry date: Dec 29, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/234
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to an improved process for the isolation and purification of aminoglycoside antibiotics of Formula (I) as defined herein combining selective lipophilization of the compound of Formula (I) in the crude product obtained by fermentation with controlled liquid/liquid extraction.