Method for reducing the pyrogen content of or removing pyrogens from substances contaminated therewith
US4381239A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 27, 1982 |
| Grant date | Apr 26, 1983 |
| Priority date | — |
| Expiry date | Jan 27, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0039
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A method for removing a pyrogen from a solution of a pyrogen-containing substance such as an amino acid, a nucleic acid base, an antibiotic, a hormone, a vitamin, an enzyme, an antibody or the like comprising contacting the solution with an adsorbent to adsorb the pyrogen, which is characterized in that the adsorbent comprises a water-insoluble carrier and a nitrogen-containing heterocyclic compound of the formula: EQU R--A--X wherein R is a nitrogen-containing heterocyclic group; A is single bond, alkylene or alkenylene; X is hydrogen or a functional group; and the heterocyclic group and alkylene may be optionally substituted by one or more substituents, and the compound being bonded to the carrier directly or through a spacer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.