Formimidoyl A and B useful as semi-synthetic aminoglycosidic antibiotics
US4382926A · kind A · utility
6Cited by
9References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 16, 1981 |
| Grant date | May 10, 1983 |
| Priority date | — |
| Expiry date | Mar 16, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/224
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New, useful derivatives of istamycins A and B are provided, which are formimidoylistamycins A and B of formula (I) having a toxicity significantly lower than those of istamycins A and B with an antibacterial activity higher than that of fortimicin A and of the same level as those of istamycins A and B. These compounds may be prepared by reacting 1,2',6'-tri-N-protected istamycins A and B of formula (V) with an iminoether.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.