Thiophene derivatives and their pharmaceutical compositions and method of use
US4382929A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 23, 1980 |
| Grant date | May 10, 1983 |
| Priority date | — |
| Expiry date | Oct 23, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which one of R.sub.1 and R.sub.2 represents hydrogen, halogen or a C.sub.1-4 alkyl group which may be optionally substituted by hydroxy or C.sub.1-4 alkoxy, and the other represents the group R.sub.4 R.sub.5 NAlk-- in which R.sub.4 represents hydrogen, C.sub.1-10 alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, heteroaralkyl, trifluoroalkyl, or alkyl substituted by hydroxy, alkoxy, amino, alkylamino, dialkylamino or cycloalkyl, and R.sub.5 represents hydrogen or a C.sub.1-4 alkyl group or R.sub.4 and R.sub.5 may, together with the nitrogen atom to which they are attached, form a 5 to 10 membered ring which may be saturated or may contain at least one double bond, may be unsubstituted or may be substituted by one or more C.sub.1-3 alkyl groups or a hydroxy group and/or may contain another heteroatom selected from oxygen and sulphur; PA0 Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms; PA0 R.sub.3, which may be in either the 2 or 3-position, represents the group ##STR2## where X represents --CH.sub.2 --, --O-- or --…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.