Ophthalmic solution for intraocular pressure reduction
US4382953A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 3, 1980 |
| Grant date | May 10, 1983 |
| Priority date | — |
| Expiry date | Sep 3, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0048
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An ophthalmic solution suitable for adjusting intraocular pressure comprising (A) an ophthalmologically acceptable, water-soluble salt of 2-acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran, (B) benzalkonium chloride or benzethonium chloride, and (C) a member selected from polyvinyl alcohol, methyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose and hydroxypropylmethyl cellulose, the solution being adjusted to pH 5.0 to 8.0 with a buffer agent. The components (B) and (C) increase greately the intraocular penetration of the component (A) and reduce the irritation to eye of the component (A) so that the pharmacological action of the component (A) can be effectively exhibited. The ophthalmic solution produces an excellent effect on decreasing of intraocular pressure with reduced irritation to eye and stability for a long term.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.