Adenosine deaminase resistant antiviral purine arabinonucleosides
US4383114A · kind A · utility
23Cited by
2References
5Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 11, 1981 |
| Grant date | May 10, 1983 |
| Priority date | — |
| Expiry date | Sep 11, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65616
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The preparation of 9-[.alpha.-(2.alpha.,3.beta.-dihydroxy-4.alpha.-(hydroxymethyl) cyclopentyl)]-6-substituted purines: ##STR1## and their derivatives wherein R is amino, mercapto, methylmercapto, hydroxy, halogen, or substituted amino: ##STR2## wherein R' and R" may be the same or different and are hydrogen, methyl, ethyl, propyl or phenyl. The compounds exhibit anti-viral and antitumor activity and are resistant to adenosine deaminase. Acid salts and esters of the purine nucleosides have also been prepared.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.