Patent · US Expired

Preparation of 3-bromo-4-fluorobenzaldehyde and its acetals

US4383949A · kind A · utility

2Cited by

0References

12Claims

0Family size

Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Fritz Maurer · Wuppertal, DE
Hans-Jochem Riebel · Bad Camberg, DE
Uwe Priesnitz · Solingen, DE
Erich Klauke

Key dates

Filing date	Jun 26, 1981
Grant date	May 17, 1983
Priority date	—
Expiry date	Jun 26, 2001

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C47/575
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A process for the preparation of a 3-bromo-4-fluorobenzaldehyde acetal of the formula ##STR1## in which R.sup.1 is methyl or ethyl, which comprises reacting a 3-bromo-4-fluoro-benzoic acid halide with ammonia to form 3-bromo-4-fluoro-benzoic acid amide, dehydrating said amide to form 3-bromo-4-fluoro-benzonitrile, reacting the nitrile with formic acid in the presence of a catalyst at a temperature between about 0.degree. and 150.degree. C. to form 3-bromo-4-fluorobenzaldehyde, and reacting said aldehyde with R.sup.1 OH or a derivative thereof capable of forming an acetal. The amide and nitrile are new compounds. The acetals are known intermediates in the synthesis of pyrethroid-like insecticides.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.