Furo-(3,4-c)-pyridine derivatives and their pharmaceutical use
US4383998A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 8, 1982 |
| Grant date | May 17, 1983 |
| Priority date | — |
| Expiry date | Jan 8, 2002 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to new 1,3-dihydro-6-methyl-7-hydroxy-furo-(3,4-c)-pyridine derivatives of the general formula ##STR1## wherein A< represents a group of the formula --(CH.sub.2).sub.n --, n being an integer of from 1 to 5, or a homocyclic or heterocyclic group, and R represents a hydrogen, chlorine or fluorine atom, a trifluoromethyl group, an alkyl group having from 1 to 5 carbon atoms, an alkoxy group having from 1 to 5 carbon atoms, a alkylthio group having from 1 to 5 carbon atoms, a dialkylaminoalkoxy group in which the alkyl groups each have from 1 to 5 carbon atoms and the alkoxy group has from 1 to 5 carbon atoms or a N-pyrolidinyl-alkoxy group in which the alkoxy group has from 1 to 5 carbon atoms to a process for the preparation of the same by refluxing .alpha..sup.4, 3-o-isopropylidene-pyridoxal with a compound of the general formula X-A-R, wherein X represents a bromine or iodine atom, in the presence of magnesium in diethyl ether, and acidifying the resultant corresponding secondary alcohol .alpha..sup.4, 3-o-isopropylidene-.alpha.-hydroxy-5-substituted-pyridoxine to break the isopropylidene ring and promote a 3,4 cyclization; and to therapeutical compositions o…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.