Antihypertensive polypeptides

US4385050A · kind A · utility

Assignee

• Armour Pharmaceutical · US

Inventors

• Karl P. Lederis · Calgary, CA
• David Stevenson · Bound Brook Junction, US
• Donald B. Olsen · Salt Lake City, US
• Charles D. Bossinger · White Plains, US
• Everett Flanigan · Kankakee, US

Key dates

• Filing date: Jun 26, 1981
• Grant date: May 24, 1983
• Expiry date: Jun 26, 2001

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/80
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptides of the structure EQU R.sub.1 --Ala--Arg--Ile--Glu--Asn--Glu--Glu--Glu--Gln--Ala--Gly--Leu--Asn--Arg--Ly s--Tyr--Leu--Val--R.sub.2 wherein PA0 R.sub.1 is hydrogen, a peptide residue containing from 1 to 18 amino acid residues, or N-acyl, and PA0 R.sub.2 is hydrogen, an alcohol moiety of an ester, an amide, or a peptide residue containing from 1 to 10 amino acid residues, wherein PA0 the acyl group is lower alkanoyl having from 1 to 8 carbon atoms, aroyl, or heterocarbonyl, and the alcohol moiety of the ester is an alkyl group having from 1 to 8 carbon atoms have antihypertensive activity.