Intermediates for preparation of 3-bromo-4-fluoro-benzyl alcohol

US4386035A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Fritz Maurer · Wuppertal, DE
• Uwe Priesnitz · Solingen, DE
• Hans-Jochem Riebel · Bad Camberg, DE
• Rainer Fuchs · Halver, DE
• Erich Klauke

Key dates

• Filing date: Sep 14, 1981
• Grant date: May 31, 1983
• Expiry date: Sep 14, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C51/56
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of 3-bromo-4-fluoro-benzyl alcohol of the formula ##STR1## comprising reacting 3-bromo-4-fluoro-benzoic acid or a derivative thereof of the formula ##STR2## in which R is a hydrogen atom, an alkyl radical or an alkoxycarbonyl radical, with a complex hydride of the formula EQU M(M'H.sub.4) in which PA1 M is lithium, sodium or potassium, and PA1 M' is boron or aluminum, at a temperature between about -20.degree. and +150.degree. C. When R is alkoxycarbonyl the starting material can be produced by reacting the corresponding free acid with a chloroformic acid ester. Compounds wherein R is alkyl or alkoxycarbonyl are new. The end product is a known intermediate for insecticides.