Chichibabin reaction
US4386209A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 8, 1982 |
| Grant date | May 31, 1983 |
| Priority date | — |
| Expiry date | Apr 8, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/82
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In a Chichibabin amination of a pyridine base by sodamide in an organic solvent, the improvement comprising conducting the reaction under pressure of at least about 50 psi in the gas phase above the reaction mixture and adding ammonia to the mixture sufficient to produce a partial pressure of ammonia of at least about 5 psi in the gas phase. Preferred temperature and pressure ranges are disclosed, as are catalysts and other preferred steps for practicing the reaction. Significant results are obtained including improved and changed yields from those classically expected in Chichibabin aminations, including new compositions of matter in at least one case.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.