N-Substituted pyruvic acid hydrazones, preparation thereof and pharmaceutical compositions containing them

US4387104A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Ruth Heerdt · Mannheim, DE
• Hans-Peter Wolff · Mannheim, DE
• Fritz Kaiser · Lampertheim, DE
• Wolfgang Schaumann · Heidelberg, DE
• Hans-Frieder Kuhnle · Weinheim, DE

Key dates

• Filing date: Aug 14, 1981
• Grant date: Jun 7, 1983
• Expiry date: Aug 14, 2001

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P3/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A pyruvic acid hydrazone derivative of the formula: ##STR1## wherein R is an aryl radical optionally substituted by lower alkyl or is an aliphatic hydrocarbon radical which can be substituted by a lower alkoxy, a cycloalkyl or an optionally substituted aryl radical, PA0 A is an alkylene radical containing 2 to 8 carbon atoms, with at least 2 carbon atoms between B and the nitrogen atom, and PA0 B is an oxygen or sulphur atom; or a physiologically acceptable salt, ester or amide thereof which possesses hypoglycaemic activity.