Heterocyclic alkylene triazinones

US4387225A · kind A · utility

Assignee

• William H. Rorer, Inc. · US

Inventors

• George H. Douglas · Paoli, US
• William L. Studt · Harleysville, US
• Chong M. Won · Warrington, US
• Stuart A. Dodson · Lansdale, US
• Jerome J. Zalipsky · Melrose Park, US

Key dates

• Filing date: May 12, 1981
• Grant date: Jun 7, 1983
• Expiry date: May 12, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Heterocyclic alkyl s-triazine compounds are prepared from the corresponding amidinourea and amidinothiourea compounds by reacting with an activated form of an acid amide to give respectively substituted s-triazinones and thiones of the formula ##STR1## which have pharmacological properties that render them suitable for use for a variety of medicinal purposes, including use as antidiarrheal agents, and which are also useful derivatives in analyzing for the corresponding amidinourea or amidinothiourea precursors.