Patent · US Expired

Process for preparing a dihydropyridine derivative

US4387230A · kind A · utility

2Cited by
3References
1Claims
0Family size

Assignee

Inventors

Key dates

Filing dateAug 20, 1981
Grant dateJun 7, 1983
Priority date—
Expiry dateAug 20, 2001

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D211/74
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

Dihydropyridines of formula ##STR1## where R.sup.6 is lower alkyl and R.sup.5 is lower alkyl or aryl (lower)alkyl are prepared by a novel process from sodium or potassium salts of 1-substituted-1,6-dihydro-5-hydroxy-3[2H]-pyridones. The dihydropyridines are useful as intermediates for pharmacologically active 1-optionally substituted-3-phenyl or substituted phenylpiperidin-5-ols and esters. Some of the piperidinols and esters are novel; those where the 1-substituent is aryl(lower)alkyl are intermediates, those where the 1-substituent is cycloalkyl(lower)alkyl are analgesics or antidepressants and those in which the 1-position is unsubstituted are anti-secretory agents.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.