Process for the preparation of p-hydroxy-benzyl-nitriles and corresponding amines
US4388250A · kind A · utility
7Cited by
3References
19Claims
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Assignee
Inventors
Key dates
| Filing date | Mar 15, 1982 |
| Grant date | Jun 14, 1983 |
| Priority date | — |
| Expiry date | Mar 15, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C255/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is provided for the preparation of p-hydroxy-benzyl-nitriles starting from the corresponding p-hydroxy-benzaldehyde, first reducing the p-hydroxy-benzaldehyde to the p-hydroxy-benzyl amine, a primary amine, with hydrogen in the presence of aqueous ammonia, preferably with the addition of small amounts of lower alkyl alcohol; and Raney nickel catalyst at low pressure; and then converting the amine to the p-hydroxy-benzyl-nitrile by reaction with sodium cyanide at elevated temperature; the first stage, the reduction, is applicable also to o- and m-hydroxy benzaldehydes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.