6-Keto-morphinan analgesics

US4388463A · kind A · utility

Assignee

• UNITED STATES OF AMERICA, AS REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES · US

Inventors

• Arnold Brossi · Bethesda, US
• Helmut Schmidhammer · Innsbruck, AT
• Arthur E. Jacobson · Rockville, US
• Fu-Lian Hsu · Potomac, US

Key dates

• Filing date: Jul 16, 1981
• Grant date: Jun 14, 1983
• Expiry date: Jul 16, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D221/28
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This patent application describes the preparation and properties of novel and highly potent morphinan analgesics. The compounds include narcotic agnoists as well as narcotic antagonists and are represented by the following formula: ##STR1## R.sub.1 =OCH.sub.3, OCOCH.sub.3, H R.sub.2 =CH.sub.3, CH.sub.2 --CH.dbd.CH.sub.2, ##STR2## CH.sub.2 CH.sub.2 C.sub.6 H.sub.5