Preparation of phenoxy-azolyl-butanone derivatives

US4388465A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Hans-Ludwig Elbe · Wuppertal, DE
• Hermann Arold · Wuppertal, DE
• Eckart Kranz
• Claus Stolzer

Key dates

• Filing date: Sep 8, 1981
• Grant date: Jun 14, 1983
• Expiry date: Sep 8, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

In the preparation of a phenoxy-azolyl-butanone derivative of the formula ##STR1## in which X is a halogen atom, PA0 Y is a hydrogen or halogen atom, and PA0 Az is an imidazolyl radical or a 1,2,4-triazolyl radical, wherein dichloropinacolin of the formula EQU Cl.sub.2 CH--CO--C(CH.sub.3).sub.3 is reacted with an azole of the formula EQU Az--H and a phenol of the formula ##STR2## in the presence of an acid-binding agent, the improvement which comprises carrying out the reaction in the presence of a water-immiscible organic solvent at a temperature between about 40.degree. and 150.degree. C., adding to the solvent at a temperature between about 0.degree. and +80.degree. C. a mineral acid, thereby to precipitate the mineral acid salt of the phenoxy-azolyl-butanone derivative, and separating such salt. Surprisingly the product does not hydrolyze when standing in contact with the mineral acid solution. The product is a known fungicide.