8-Arylalkyl-3-phenyl-3-nortropanols and salts thereof

US4393069A · kind A · utility

Assignee

• C. H. Boehringer Sohn · DE

Inventors

• Adolf Langbein
• Herbert Merz · Ingelheim am Rhein, DE
• Rainer Sobotta · Ingelheim am Rhein, DE
• Rudolf Bauer · Hallerndorf, DE
• Hans Michael Jennewein · Wiesbaden, DE
• Joachim Mierau · Mainz, DE

Key dates

• Filing date: Nov 25, 1981
• Grant date: Jul 12, 1983
• Expiry date: Nov 25, 2001

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P5/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein Ar is ##STR2## R.sub.1 is hydrogen, fluorine, bromine, methyl or methoxy; X is .dbd.CO, .dbd.CH--CN, .dbd.CH--OH, --O--, --S--, --NH--, ##STR3## and R is hydrogen, 4-fluoro, 4-chloro, 4-trifluoromethyl, 3-trifluoromethyl, 3-trifluoromethyl-4-chloro, 4-methyl or 4-methoxy; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as neuroleptics.