Bone graft material for osseous defects and method of making same
US4394370A · kind A · utility
Inventor
Key dates
| Filing date | Sep 21, 1981 |
| Grant date | Jul 19, 1983 |
| Priority date | — |
| Expiry date | Sep 21, 2001 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/84
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Complexes of reconstituted collagen and demineralized bone particles or reconstituted collagen and a solubilized bone morphogenetic protein fabricated in a sponge suitable for in vivo implantation in osseous defects are disclosed. Both demineralized bone particles (DBP) and bone morphogenetic protein have demonstrated the ability to induce the formation of osseous tissue in animal and human experiments. Reconstituted collagen conjugate is highly biocapatible and can be fabricated in a variety of configurations, especially as a sponge. This material can be used as a grafting implant in plastic and reconstructive surgery, periodontal bone grafting, and in endodontic procedures. Structural durability is enhanced by cross-linking with glutaraldehyde which is also used to sterilize and disinfect the collagen conjugate prior to implantation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.