Unsymmetrically substituted dicarboxylic-acid-bis-(2,4,6-triiodo-anilides), their preparation, and x-ray contrast media containing same

US4395391A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Heinrich Pfeiffer · Eppingen, DE
• Wolfgang Mutzel · Berlin, DE
• Ulrich Speck · Berlin, DE

Key dates

• Filing date: Nov 24, 1981
• Grant date: Jul 26, 1983
• Expiry date: Nov 24, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C233/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Unsymmetrically substituted dicarboxylic-acid-bis-(2,4,6-triiodo-anilides) of formula I ##STR1## wherein X is straight-chain or branched alkylene interrupted by one or more oxygen atoms, PA0 R.sup.1 is --NHacyl, --CH.sub.2 NHacyl, or --CONHR.sup.3 wherein R.sup.3 is hydrogen or a lower straight-chain or branched optionally mono- or poly-hydroxylated, alkyl residue, and where any hydroxyl groups present may be functionally modified, and PA0 R.sup.2 is hydrogen or lower alkyl, and their salts, are extraordinarily well suited, in view of their good pharmacological and physico-chemical properties, as water-soluble x-ray contrast media for all fields of application, in particular for i.v. cholegraphy and for computer tomography.