Oxime ethers and pharmaceutical compositions containing the same
US4395413A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 24, 1980 |
| Grant date | Jul 26, 1983 |
| Priority date | — |
| Expiry date | Jun 24, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to novel oxime ethers of the general formula /I/ and acid addition salts and quaternary ammonium derivatives thereof, ##STR1## wherein A represents a C.sub.2-6 straight or branched alkylene chain, PA0 R and R.sup.1 each represent a C.sub.1-6 alkyl group or they form together with the adjacent nitrogen atom a heterocyclic ring containing 4 to 7 carbon atoms and optionally a further hetero atom, i.e. an oxygen, sulfur or nitrogen atom, and said ring may be optionally substituted by a C.sub.1-3 alkyl, phenyl or benzyl group, PA0 R.sup.2 and R.sup.3 each denote a hydrogen atom or together form a valency bond, PA0 R.sup.4 denotes a C.sub.1-10 alkyl or C.sub.2-10 alkenyl group, and PA0 n denotes an integer from 3 to 7. The compounds of the general formula /I/ are prepared according to the invention by reacting a cycloalkane derivative of the general formula /II/ ##STR2## wherein R.sup.2, R.sup.3, R.sup.4 and n have the same meaning as above, whereas PA0 Y denotes an oxygen or sulphur atom or a .dbd.N--OH group with an aminoalkyl derivative of the general formula /III/ ##STR3## wherein R, R.sup.1 and A have the same meaning as stated above and PA0 Z means a halogen a…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.