Substituted quinolinone-alkanecarboxylic acids and medicaments containing them, having a hyperglycaemic action

US4395414A · kind A · utility

Assignee

• Byk Gulden Lomberg Chemische Fabrik GmbH · DE

Inventors

• Klaus Eistetter · Konstanz, DE
• Erich Rapp · Radolfzell, DE
• Horst Wolf · Konstanz, DE

Key dates

• Filing date: Apr 21, 1981
• Grant date: Jul 26, 1983
• Expiry date: Apr 21, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/38
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Quinolinone-alkanecarboxylic acids of the formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are identical or different and denote hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group with 1 to 4 carbon atoms, an amino group, a dialkylamino group, the alkyl radicals having 1 to 4 carbon atoms, or a nitro group, PA0 R.sup.4 and R.sup.5 are identical or different and denote a hydrogen atom, a halogen atom, an alkoxy group with 1 to 4 carbon atoms, a hydroxyl group, an amino group or a dialkylamino group, the alkyl radicals having 1 to 4 carbon atoms, or PA0 R.sup.4 and R.sup.5 together denote a methylenedioxy group bonded to two adjacent ring carbon atoms, and A denotes an alkylene group with 1 to 5 carbon atoms, and esters thereof with alkanols with 1 to 5 carbon atoms, and salts thereof with inorganic and organic bases are new compounds. They display a hyperglycaemic action in warm-blooded animals. Processes for the preparation of the new compounds are given.