1-Spiro isobenzofuranic and 1-spiro isobenzothiophenic derivatives the process for preparing the same and their use in therapeutics
US4395416A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 21, 1982 |
| Grant date | Jul 26, 1983 |
| Priority date | — |
| Expiry date | Jan 21, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Derivatives of formula: ##STR1## in which Z< represents: either an amino group of struture >N-R.sub.1 where R.sub.1 represents a linear or branched alkyl group with 1 to 5 carbon atoms or a phenyl group possibly substituted by a chlorine atom, in which case: PA2 n=1 or 2, PA2 the pair (A, C X) assumes the following values: (S, C.dbd.O), (S, CH.sub.2), (O, CH.sub.2), (O, CH--C.sub.6 H.sub.5), and PA2 R represents a hydrogen or halogen atom, one or more methoxy groups or the butadiene-1,3 ylene chain ##STR2## fixed in position 5,6 of the phenyhl nucleus and thus forming with this latter a naphthyl nucleus; PA1 or a methylene group (--CH.sub.2 --), in which case: PA2 n=1 or 2, PA2 A represents the oxygen atom, PA2 >C X represents a carbonyl group (>C.dbd.O) or thiocarbonyl group (>C.dbd.S), and PA2 R has the same meanings as previously, as well as the mineral or organic acid addition salts thereof. The compounds exhibit anti-convulsion and analgesic activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.