Penem-3-carboxylic acid derivatives
US4395418A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 5, 1981 |
| Grant date | Jul 26, 1983 |
| Priority date | — |
| Expiry date | Jun 5, 2001 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Penem-3-carboxylic acid derivatives of formula (I): ##STR1## (wherein: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group, a hydroxyalkyl group, an acyloxyalkyl group, an alkylsulphonyloxyalkyl group, an arylsulphonyloxyalkyl group or a trialkylsilyloxyalkyl group; PA1 R.sup.2 represents a hydrogen atom or an alkyl group; PA1 R.sup.3 represents a hydrogen atom, an amino-protecting group or a group of formula ##STR2## in which R.sup.5 and R.sup.6 are the same or different and each represents a hydrogen atom or an alkyl group; PA1 A represents a branched-chain alkylene group; and PA1 R.sup.4 represents a carboxy group or a protected carboxy group) and pharmaceutically acceptable salts thereof, may be prepared by heating a corresponding phosphorus-ylide compound or by reacting a corresponding azetidin-2-one with a suitable phosphorous acid triester or triamide, and have been found to have excellent antibacterial activity accompanied by a very low acute toxicity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.