Synthesis of 3-hydroxyoxetane
US4395561A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 14, 1982 |
| Grant date | Jul 26, 1983 |
| Priority date | — |
| Expiry date | May 14, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D309/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing 3-hydroxyoxetane comprising the following steps in order PA0 (1) reacting a carboxylic acid of the formula CH.sub.3 (CH.sub.2).sub.n COOH with epichlorohydrin in the presence of anhydrous ferric chloride to produce an ester of the formula ##STR1## wherein n is an integer of from 0 to 3; (2) protecting the secondary hydroxy group of the ester with a blocking group, Z, that is stable to bases; thus forming a blocked ester of the formula ##STR2## (3) hydrolyzing the blocked ester formed in step (2) with an aqueous base to remove the carboxylic acid and form a 3-hydroxyoxetane derivative of the formula ##STR3## in which Z represents the blocking group; (4) removing the blocking group from the 3-hydroxyoxetane derivative by heating it with an alcohol and an acid to form the product 3-hydroxyoxetane, ##STR4##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.