Aminocyclitol antibiotics, pharmaceutical compositions and method of using same
US4396609A · kind A · utility
7Cited by
5References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 6, 1977 |
| Grant date | Aug 2, 1983 |
| Priority date | — |
| Expiry date | Sep 6, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D303/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Aminocyclitol analogs of gentamicin C.sub.1, C.sub.2 and C.sub.1a and the corresponding compounds acylated on the 1-, 3- and 2'-amino groups with an .omega.-amino-.alpha.-hydroxy-lower-alkanoyl group are prepared by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and an added aminocyclitol with a mutant of Micromonospora purpurea and acylating the product with an ester of an .omega.-(N-benzyloxycarbonyl)amino-.alpha.-hydroxy-lower-alkanoic acid followed by catalytic hydrogenolysis of the benzyloxycarbonyl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.